GENETIC TESTING
In order to ensure your puppy free from the following inheritable disorders, we have had our dogs genetically profiled.
Centronuclear Myopathy (CNM)
Centronuclear myopathy, previously known as HMLR, or Hereditary Myopathy, is an autosomal recessive mutation that causes insufficient muscle function in retrievers. This is due to the centralization of the nuclei in muscle fibers, caused by an missense insertion in the PTPLA gene.
Centronuclear myopathy is a recessive disorder, meaning that the dog must have two copies of the defective gene to suffer from the disease. Because CNM is a recessive disorder, a dog can also be a carrier of this disease, meaning it carries one copy of the mutation, but does not display any symptoms. A carrier dog can pass on this mutation to their offspring, and if they mate with another carrier dog, can produce offspring affected by Centronuclear Myopathy.
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Exercise-Induced Collapse (EIC)
Exercise-Induced Collapse is a genetic disorder causing affected dogs to suffer from a loss of muscle control following periods of extreme exercise. This disorder is caused by a mutation in the Dyamin 1 gene. Because EIC is a recessive disorder, a dog must have two copies of the mutation in order for the disease to manifest.
Typically, an affected dog begins to show symptoms between 5 months and 3 years of age.
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Degenerative Myelopathy (DM)
Canine degenerative myelopathy (also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. The disease has an insidious onset typically between 7 and 14 years of age. It begins with a loss of coordination (ataxia) in the hind limbs.
As of July 15, 2008 the mutated gene responsible for DM has been found present in 43 breeds including Chesapeake Bay Retrievers. The disease is chronic and progressive, and resulting in paralysis.
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Centronuclear myopathy is a recessive disorder, meaning that the dog must have two copies of the defective gene to suffer from the disease. Because CNM is a recessive disorder, a dog can also be a carrier of this disease, meaning it carries one copy of the mutation, but does not display any symptoms. A carrier dog can pass on this mutation to their offspring, and if they mate with another carrier dog, can produce offspring affected by Centronuclear Myopathy.
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Exercise-Induced Collapse (EIC)
Exercise-Induced Collapse is a genetic disorder causing affected dogs to suffer from a loss of muscle control following periods of extreme exercise. This disorder is caused by a mutation in the Dyamin 1 gene. Because EIC is a recessive disorder, a dog must have two copies of the mutation in order for the disease to manifest.
Typically, an affected dog begins to show symptoms between 5 months and 3 years of age.
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Degenerative Myelopathy (DM)
Canine degenerative myelopathy (also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. The disease has an insidious onset typically between 7 and 14 years of age. It begins with a loss of coordination (ataxia) in the hind limbs.
As of July 15, 2008 the mutated gene responsible for DM has been found present in 43 breeds including Chesapeake Bay Retrievers. The disease is chronic and progressive, and resulting in paralysis.
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